Creator
25:17A solo podcast host scrolls through one whiteboard doc, thirteen cards deep, arguing that every durable business left to build either delivers work through agents or owns the thing agents still can't replace.
October 6th
18:56Greg Isenberg watches sixty minutes of Sam Altman's Dev Day keynote and picks the four launches, out of more than twenty, that he thinks hand outside builders a real business.
September 29th
29:49Greg Isenberg breaks down how Thrive Capital and General Catalyst are buying small service firms and running AI agents inside them, then lays out the exact folder structure, agent pipeline, and weekly routine for running a one-person version.
September 28th
48:05Greg Isenberg builds a one-person creative agency where Astra plans and repairs the work, 50+ Higgsfield models produce it, and he just approves the output and gets paid.
September 23rd
Video of the Day1:09:34A ghostwriter turned SaaS founder explains why AI can't invent your point of view, it can only repeat what you've already written down.
September 21st
28:24Greg Isenberg and Ryan Vogel introduce Jev, a probability-only AI model built to make split-second business decisions instead of writing paragraphs.
September 18th
27:30Greg Isenberg and Remy put the invite-only Instinct agent through real errands, a haircut, a restaurant table, and a Bali visa, and find out it keeps a copy of your email even after you disconnect it.
September 15th
31:29Startup Ideas host Greg Isenberg gets engineer Ras Mic to open his actual agents.md file and walk through the isolate-build-prove-ship loop he runs on real pull requests.
September 14th
22:52A two-person breakdown of OpenAI's top-tier model that skips the game demos and goes straight to code audits, nine money-making agent prompts, and a Raspberry Pi speaker built and shipped in about 30 minutes.
September 10th
38:46A solo-cast map of the local AI stack, from Hugging Face and Gemma model sizes to three niche businesses built on models that never leave the machine.
September 8th
24:43A solo walkthrough of five open-source GitHub repos getting traction right now, an AI writing editor, an agent-run CRM, a video-editing agent, a skill security scanner, and a phone-controlling harness, each with the exact install command and the first small workflow to try.
September 2nd
35:18Greg Isenberg names the role he thinks AI agents are about to make the most valuable job in tech, and hands over the folder structure, tool stack, and 30-day plan to become one.
August 31st
28:58Greg Isenberg and developer Vinny break down WebMCP, the experimental browser feature that lets any AI agent search, compare, and buy on a website without scraping the page, then price two startup ideas built on it.
August 26th
44:21Billy Howell walks through the AI agent team that runs his local newsletter end to end, and the four-week plan for building the same thing yourself.
August 21st
48:10Greg Isenberg's nine-part framework for turning Claude Code into a 24/7 AI employee, walked through live on a real med-spa idea, from workspace and memory files to scheduled routines and parallel agent sessions.
August 17th
48:28Allie K. Miller tells Greg Isenberg why she stopped managing her 34 AI agents and started running them like a company she's three rungs above.
August 12th
34:10Cloudflare quietly built the payment rail for AI agents to pay tiny fees for web resources, and that rail is about to spawn a whole generation of businesses selling clean data, agent-readiness, and packaged expertise.
August 10th
Video of the Day43:59Cody Schneider returns to build two marketing agents live on screen — a cold-outbound machine that turns LinkedIn engagement into enriched leads, and an organic engine that turns internal conversations into a daily content pipeline.
August 5th
26:28A solo breakdown of graph engineering: why one AI model researching, writing, and grading its own answer is worse than jobs, arrows, and a human gate.
August 3rd
38:44Greg Isenberg gets a live, screen-shared tour of Jack Dorsey's new agent-native chat app from an early user — and presses him on whether it actually beats Slack.
July 28th
Video of the Day37:47Cody Schneider maps the exact infrastructure — pipeline, warehouse, agent — behind a Facebook ads system that researches, creates, publishes, and kills its own losing ads.
July 27th
44:47Ryan Carson explains why running a one-person AI startup in 2026 means becoming a full-time manager of cloud coding agents, not a part-time coder.
July 24th
51:34Greg Isenberg sits down with Varick Agents CEO Vas to reverse-engineer the forward deployed engineer role — and hand over a 30-day plan to become one.
July 20th
1:01:05Corey Ganim opens his full $999 AI Tools Assessment playbook — four fulfillment phases, six upsells, and seven ways to land clients with zero capital or audience.
July 15th